Medical College Researcher to Study Glaucoma

Feb. 3, 2012

The Medical College of Wisconsin received a five-year, $1.9 million grant from the National Institutes of Health’s National Eye Institute to investigate the mechanisms underlying the development of glaucoma.
Brian Link, Ph.D., professor of cell biology, neurobiology and anatomy, is the principal investigator for the grant.
Glaucoma is an eye disease in which elevated pressure within the eye damages the optic nerve, leading to visual impairment. There are several types of glaucoma that affect an estimated 2.2 million Americans. Many obstacles, however, stand between scientists and the discovery of the genes that impact glaucoma in humans. Dr. Link and his lab are reducing these obstacles by developing techniques to explore the roots of the disease using zebrafish. Using zebrafish, Dr. Link’s lab isolated the bugeye mutations in lrp2, a large receptor protein. Zebrafish with lrp2 mutations show the same symptoms as glaucoma: increased ocular pressure, nearsightedness, and optic nerve damage.
In this study, Dr. Link along with Kerry Veth and Dr. Ross Collery , research associates in his lab, will examine the genes associated with mutations that produce glaucoma-associated effects. This team will conduct experiments to identify the signaling pathways by which the mutated genes are expressed into these debilitating symptoms. Dr. Link also seeks to identify new genes connected with glaucoma-associated conditions.
Glaucoma is a multi-factorial disease, and Dr. Link’s research will help define the cellular and molecular activities involved.


Community Watch

» Anodyne Coffee plans to open location in Wauwatosa Village Updated:  7/29

» Initial Reaction Podcast: Menomonee Falls baseball virtuoso Ty Weber and Big Ten Media Day Updated:  7/29

» Wauwatosa West girls basketball coach Ashley Imperiale resigns 7/26

» Store owners, police weigh in on string of protests at Mayfair mall Updated:  7/26

» Tosa police will not release squad video of officer-involved shooting Updated:  7/25

» Wauwatosa school district files lawsuit against WIAA over conference realignment Updated:  7/25

» Protest over fatal shooting forces brief closure of Mayfair Mall 7/23

» Reports into fatal Wauwatosa police shooting delivered to DA 7/22

» Social media story on the storms rolling through Milwaukee area 7/21

» Business Spotlight: Cranky Al's has grown from desperation to a Wauwatosa institution Updated:  7/20

» Initial Reaction Podcast: Wisconsin Badgers football, WIFCA All-Star game 7/20

» Michaelis leads Wauwatosa East past rival West in regional 7/20

» Milwaukee County Chargers earn overtime win over Muskego 7/20

» Activists push DA for disclosure on police killing in Wauwatosa 7/19

» Video: How a Pokémon Go newbie experienced the craze playing in Wauwatosa Updated:  7/19

» Tosa police, firefighters celebrated during First Responders Fest 7/18

» Ray's Wine & Spirits in Tosa celebrates 55 years with public party 7/15

» Wauwatosa's Relay for Life event slated for July 22 7/14

» Wauwatosa Mayor Kathy Ehley receives award for business leadership 7/14

» Video: Mayfair Collection's Bartolotta restaurants billed as 'triple threat' Updated:  7/14

» Bus rapid transit route clears two hurdles 7/13

» A look at the French restaurant Cafe Grace, opening Tuesday in Wauwatosa 7/13

» Wauwatosa West baseball team drops four of last five games 7/12

» Wauwatosa East baseball team falls to Marquette in Greater Metro semifinals 7/12

» Coalition for Justice, Black Lives Matter protest in Milwaukee, Tosa Updated:  7/12

View All Posts Got a tip? Welcome rss

Best Summer Ever


We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.



Hidden Tosa


"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.