CTSI funds ovarian cancer research

Aug. 21, 2014

A research scientist from the Medical College of Wisconsin (MCW) has received a three-year Mentored Career Development Award from the Clinical & Translational Science Institute of Southeast Wisconsin (CTSI) to study the effects of mesothelial cells on patient-derived ovarian cancer spheroids (clusters of ovarian cancer cells).

Erin Bishop, M.D., assistant professor of obstetrics and gynecology at MCW and a practicing gynecologic oncologist at Froedtert Hospital, is the recipient of one of four grants awarded this year by the CTSI. The grant provides up to $140,000 per year in salary and benefits, as well as $25,000 to support her research. In addition to the financial support, the grant also provides mentored training opportunities for junior faculty working in clinical and translational research who want to become dedicated, independently funded researchers. Dr. Bishop’s mentor over the next three years is Ramani Ramchandran, Ph.D., vice chair of Research Obstetrics and Gynecology, Patrick J. and Margaret G. McMahon Professor of Obstetrics and Gynecology, professor of pediatrics and developmental biology and human molecular embryology at the MCW, and an investigator at the Children’s Hospital of Wisconsin Research Institute.

Mesothelial cells are cells that line the internal organs and body wall around the abdomen, the lungs, and the heart. The goal of this project is to investigate the effects of mesothelial cells on adhesion and invasion of patient-derived ovarian cancer spheroids (3-dimensional cells) compared to single ovarian cancer cells in vitro, or studied outside normal biological context.

Drs. Bishop and Ramchandran will also focus on the clinical behavior of patient-derived ovarian cancer spheroids compared to single cells and determine if spheroids resist chemotherapy. Doing so will help determine the role of mesothelial cells in triggering ovarian cancer spheroid linkage, invasion, and spreading of cancer cells.

The goal of the CTSI is to create synergy through collaboration, and studies are specifically designed to lead to major future research support. The projects explore findings that have the potential to be translated into clinical practice and community health, and are led by investigators at the CTSI’s eight partnering institutions: the Medical College of Wisconsin, Marquette University, Milwaukee School of Engineering, UW-Milwaukee, Froedtert Hospital, Children’s Hospital of Wisconsin, the Clement Zablocki VA Medical Center, and Blood Center of Wisconsin.

CTSI is one of only 62 medical research institutions funded by the National Institutes of Health (NIH). Working together, the CTSI institutions are committed to improving human health by streamlining science, transforming training environments and improving the conduct, quality and dissemination of clinical and translational research. The CTSI program is led by the National Center for Advancing Translational Sciences (NCATS), part of the NIH.

Support for the Mentored Career Development Award Program is provided through the CTSI.

Community Watch

» Anodyne Coffee plans to open location in Wauwatosa Village Updated:  7/29

» Initial Reaction Podcast: Menomonee Falls baseball virtuoso Ty Weber and Big Ten Media Day Updated:  7/29

» Wauwatosa West girls basketball coach Ashley Imperiale resigns 7/26

» Store owners, police weigh in on string of protests at Mayfair mall Updated:  7/26

» Tosa police will not release squad video of officer-involved shooting Updated:  7/25

» Wauwatosa school district files lawsuit against WIAA over conference realignment Updated:  7/25

» Protest over fatal shooting forces brief closure of Mayfair Mall 7/23

» Reports into fatal Wauwatosa police shooting delivered to DA 7/22

» Social media story on the storms rolling through Milwaukee area 7/21

» Business Spotlight: Cranky Al's has grown from desperation to a Wauwatosa institution Updated:  7/20

» Initial Reaction Podcast: Wisconsin Badgers football, WIFCA All-Star game 7/20

» Michaelis leads Wauwatosa East past rival West in regional 7/20

» Milwaukee County Chargers earn overtime win over Muskego 7/20

» Activists push DA for disclosure on police killing in Wauwatosa 7/19

» Video: How a Pokémon Go newbie experienced the craze playing in Wauwatosa Updated:  7/19

» Tosa police, firefighters celebrated during First Responders Fest 7/18

» Ray's Wine & Spirits in Tosa celebrates 55 years with public party 7/15

» Wauwatosa's Relay for Life event slated for July 22 7/14

» Wauwatosa Mayor Kathy Ehley receives award for business leadership 7/14

» Video: Mayfair Collection's Bartolotta restaurants billed as 'triple threat' Updated:  7/14

» Bus rapid transit route clears two hurdles 7/13

» A look at the French restaurant Cafe Grace, opening Tuesday in Wauwatosa 7/13

» Wauwatosa West baseball team drops four of last five games 7/12

» Wauwatosa East baseball team falls to Marquette in Greater Metro semifinals 7/12

» Coalition for Justice, Black Lives Matter protest in Milwaukee, Tosa Updated:  7/12

View All Posts Got a tip? Welcome rss

Best Summer Ever

 

We've made it easy for you to get out and go this summer. From hitting the trails for a bike ride or walk, to where to find beer gardens in the area, to the best places to swim in Waukesha County to the best summer drinks and summer reads, check out our 2016 summer guide.

Advertisement

Advertisement

Hidden Tosa

 

"Hidden Tosa" is a semi-regular feature where our Wauwatosa reporter explores the closed down and closed off parts of Wauwatosa.

Advertisement

CONNECT